Rachel Linderman, Aadhi1 Balasubramanian, Madeline Pflasterer-Jennerjohn, Lucas Maakested, Jeong W. Pak, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To assess an artificial intelligence (AI)-based OCT segmentation with the ability to segment …
Age-Related Macular Degeneration
Association of RPD with Early Stage of AMD
Jeong W. Pak, David Lopez, Emily Y. Chew, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Reticular pseudodrusen (RPD) is associated with increased risk of progression to late age-related macular degeneration (AMD), particularly geographic atrophy (GA). …
Characterizing Intermediate AMD Biomarkers on OCT: Methods and Reproducibility
Jennifer Heathcote, Jordan Winkler, Jeong W. Pak, Rick Voland, Barbara Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and assess intergrader agreement for intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers in …
Ellipsoid Zone Integrity Index: A Novel OCT Biomarker in AMD
Bethany M. Erb, Elaine Botros, Thomas F. Saunders, Anna-Maria Haas, Rick Voland, Rachel Linderman, Barbara A. Blodi, Amitha Domalpally, Karl G. Csaky Abstract Purpose: Change in geographic atrophy (GA) area as measured by fundus autofluorescence …
Characterization of OCT biomarkers and endpoints in intermediate AMD
Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and intergrader agreement for assessing intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers …
Longitudinal Analysis of Age-Related Macular Degeneration in the AMD Ryan Initiative Study (ARIS) (2023)
Jeong W. Pak, Gelique Ayala, Cynthia Hurtenbach, Christine Orndahl, Tiarnan DL Keenan, Frederick L. Ferris, C. P Wilkinson, Traci Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year observational study of participants …
Multimodal Assessment of Incomplete Retinal Pigment Epithelial Outer Retinal Atrophy (iRORA) and Nascent Geographic Atrophy (nGA) in Age-Related Macular Degeneration (2023)
Gelique Ayala, Jeong Pak, Kenny Taylor, Cynthia Hurtenbach, Barbara Blodi, and Amitha Domalpally Abstract Purpose: To compare SD-OCT defined iRORA and nGA lesions to Fundus Autofluorescence (FAF) and Color Fundus Photography (CFP) Methods: Subjects enrolled …
Multimodal Imaging Evaluation of Age-Related Macular Degeneration (AMD) in the AMD Ryan Initiative Study (ARIS) (2022)
Andrew Dieu, Cynthia Hurtenbach, Jeong W. Pak, Tiarnan D. Keenan, Frederick L. Ferris, Charles P. Wilkinson, Christine Orndahl, Traci E. Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year, multicenter, international, prospective, …
Comparable Growth Rates of Bilateral Geographic Atrophy due to Age-related Macular Degeneration (2019)
Jeong W. Pak, Amitha Domalpally, Kyle McDaniel, Barbara Blodi Abstract Purpose: To evaluate growth rate and characteristics of bilateral geographic atrophy (GA) associated with age-related macular degeneration (AMD) from fundus color and autofluorescence images Methods: …
Drusen Area Measured from Color Photographs Compared to RPE and Drusen Volume from SD-OCT in Eyes with AMD over One Year (2017)
Ronald P Danis, Amitha Domalpally, Ralph Trane, Jeong W Pak Abstract Purpose: To quantitatively evaluate the relationship between drusen area from photographs and drusen [a1.1]volume from SDOCT volume scans with respect to baseline association, AREDS …
Standardized Assessment of Drusen Measurements from SDOCT Scans in Dry Age Related Macular Degeneration (2015)
Amitha Domalpally, Yijun Huang, Dawn Myers, Taylor Starnes, Zhe Liu, Ronald P. Danis, Barbara A. Blodi Abstract Purpose: To compare retinal pigment epithelium (RPE) and retinal thickness assessments made with SDOCTin eyes with dry AMD …
Ultra Wide Field Autofluorescence Imaging in Age Related Macular Degeneration Optos Peripheral Retina (OPERA) Age Related Eye Disease Study 2 (AREDS2) Ancillary Study (2014)
Amitha Domalpally, Ronald Danis, Emily Chew, Srinivas Sadda, Traci Clemons, Thomas R Friberg, and the AREDS2 Research Group Abstract Purpose: To characterize abnormalities in the peripheral retina using ultrawidefield (UWF) autofluorescence (AF) images in eyes …
Morphological characteristics associated with drusen progression on Spectral Domain OCT (SD-OCT) (2013)
Jeong W. Pak, Amitha Domalpally, Dawn Myers, Xiufen Yang, Ashwini Narkar, Yijun Huang, and Ronald P. Danis Abstract Purpose: To characterize drusen morphology and retinal layer abnormalities by simple, ordinal description and to associate these …
Evaluation of Precursors of Geographic Atrophy associated with Age-Related MMacular Degeneration (AMD) in the Age-Related Eye Disease Study 2 (AREDS2) (2010)
Jane R. Armstrong, James White, Amitha Domalpally, Ronald P. Danis, Barbara Blodi, Qian Peng, Michael L. Klein, AREDS2 Research Group. Abstract Purpose: To assess retinal precursors of Geographic atrophy (GA) in digital images from the …
Reproducibilty of Classification by AREDS Severity Scale and Component Features in AREDS2 (2009)
Ronald P. Danis, Jane Armstrong, Qian Peng, Amitha Domalpally, Larry Hubbard, and the AREDS2 Research Group Abstract Purpose: The 11-step AREDS Severity Scale for age related macular degeneration (AMD) cross tabulates macular features from stereoscopic …
Rationale and Transition from Multistep Grading to Single Step Grading of Retinal Images at a Reading Center (2009)
Qian Peng, Ronald P. Danis, Amitha Domalpally, Larry Hubbard, Jane Armstrong, and the AREDS2 Research Group Abstract Purpose: In the Age-Related Eye Disease Study 2 (AREDS2), a large multicenter clinical trial of nutritional supplements on …
Calcified Drusen as a Baseline Risk Factor for Progression to Advanced Age-Related Macular Degeneration from the Age-Related Eye Disease Study (2006)
Jane Armstrong, Ronald Danis, Matthew D. Davis , B. Zhang, L. –Y. Lee, Ronald Klein, Barbara E. Klein, Larry D. Hubbard Abstract Purpose: To analyze the presence of calcified drusen as a baseline risk factor …
Illustration of the AMD Severity Scale from the Age-Related Eye Diseases Study (2004)
Jane Armstrong, Matthew D. Davis, R.E. Gangnon, L. –Y. Lee, Ronald Klein, Barbara E. Klein, R. C. Milton, F.L. Ferris, Larry D. Hubbard Abstract Purpose: To summarize the AREDS severity scale for age–related macular degeneration …