Cole Bacig, Nancy Barrett, Kristi Dohm, Amitha Domalpally, Barbara Blodi Abstract Purpose: The gold standard for diabetic retinopathy (DR) evaluation is the Early Treatment Diabetic Retinopathy Study (ETDRS) 12-step severity scale (DRSS), based on stereoscopic …
ARVO 2025
Characterizing Intermediate AMD Biomarkers on OCT: Methods and Reproducibility
Jennifer Heathcote, Jordan Winkler, Jeong W. Pak, Rick Voland, Barbara Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and assess intergrader agreement for intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers in …
Comparison of Measurement Techniques for Photoreceptor Loss in Geographic Atrophy
Maria Schulz, Sairi Zhang, Jeong W. Pak, Rick Voland, Mark Banghart, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: This study compares two methods for assessing ellipsoid zone (EZ) loss on optical coherence tomography (OCT): traditional …
Ellipsoid Zone Integrity Index: A Novel OCT Biomarker in AMD
Bethany M. Erb, Elaine Botros, Thomas F. Saunders, Anna-Maria Haas, Rick Voland, Rachel Linderman, Barbara A. Blodi, Amitha Domalpally, Karl G. Csaky Abstract Purpose: Change in geographic atrophy (GA) area as measured by fundus autofluorescence …
Multimodal Imaging Assessment of Risk Factors for GA Progression
Thomas Saunders, Jeong W. Pak, Rick Voland, Karl G. Csaky, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a multifactorial disease posing challenges in predicting progression. While prior studies have identified key …
AI-enabled multi-disease OCT segmentation
Caleb Pacheco, Rachel E. Linderman, Madeline Pflasterer-Jennerjohn, Mark Banghart, Robert D. Slater, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop an artificial intelligence (AI) enabled OCT segmentation algorithm specifically tailored for diabetic macular edema (DME), …
OCT Risk Factors for Geographic Atrophy Progression
Jeong W. Pak, Thomas Saunders, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a complex disease with challenges in predicting its progression. While previous studies have highlighted key risk factors …
Deep Learning-Based Quantification of GA Area on OCT Scans
Rushi N. Mankad, Madeline Pflasterer-Jennerjohn, Rachel E. Linderman, Robert Slater, Amitha Domalpally Abstract Purpose: The consensus of Atrophy (CAM) criteria provides a robust framework for evaluating geographic atrophy (GA) with optical coherence tomography (OCT) scans. …
Artificial Intelligence (AI) enabled pre-screening for Diabetic Retinopathy (DR) clinical trials
Nancy Barrett, Robert Slater, Rachel E. Linderman, Rick Voland, Claire Calhoun, Jennifer K. Sun, Barbara A. Blodi, Amitha Domalpally, with the DRCR Retina Network Abstract Purpose: Preventive strategies to slow progression of diabetic retinopathy (DR) …
Characterization of OCT biomarkers and endpoints in intermediate AMD
Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and intergrader agreement for assessing intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers …
Diabetic Retinal Disease Characterization: Electronic Health Record Data Compared To Reading Center Grading Of Fundus Images
Kristi Dohm, Mozhdeh Bahrainian, Nancy Barrett, Rick Voland, John Garrett, Jomol Mathew, Michael D. Abramoff, Barbara Blodi, Amitha Domalpally, Roomasa Channa Abstract Purpose: Validity of diabetic retinal disease (DRD) severity level as documented in electronic …
AI-based Measurement of GA Area for Screening In Clinical Trials
Mohammed Younis, Robert D. Slater, Caleb Pacheco, Sairi Zhang, Rick Voland, Rachel E. Linderman, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop and validate a transfer learning model for measuring geographic atrophy (GA) area using …
Methodology and Reproducibility of Nonperfusion Area on UWF-FA
Mary Wilda, Rachel Halweg, Cynthia Hurtenbach, Kristi Dohm, Justin Parks, Ruth Shaw, Sheila Watson, Kari Moseman, Rick Voland, Barbara A. Blodi Abstract Purpose: To investigate the reproducibility of nonperfusion area measurements from ultrawide field fluorescein …
Predicting Geographic Atrophy Risk Using Autofluorescence Imaging and Artificial Intelligence
Robert D. Slater, Apoorva Safai, Madeline Pflasterer-Jennerjohn, Jennifer Heathcote, Rachel E. Linderman, Pallavi Tiwari, Emily Chew, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is the end stage of non-exudative AMD. Prevention strategies are essential to …
Comparison of GA measurements among ORC, OCT, and FAF imaging
Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) …
Correlating Fundus Flavoprotein Fluorescence with Structural Changes in Geographic Atrophy
Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration …