Shelby Storm, Madeline Pflasterer-Jennerjohn, Robert Slater, Rachel Linderman, Jeong W. Pak, David Lopez, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Ellipsoid zone (EZ) loss is increasingly used as an endpoint in geographic atrophy (GA) trials, …
GA
Real World Validation of Optos AI Algorithm for GA area Measurement
Reeva Faisal, Caleb Pacheco, Robert Slater, Mohammed S. Younis, Jomol Matthew, Marine Nalbandyan, Amitha Domalpally, Roomasa Channa Abstract Purpose: Optos ultrawide field imaging is widely used in routine care to monitor Geographic Atrophy (GA) progression …
Real World Deployment of a Prescreening Algorithm for Geographic Atrophy
Thomas Saunders, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Area of geographic atrophy (GA) is a primary enrollment criterion in clinical trials. Current practices rely on clinicians to screen subjects for …
Comparison of Measurement Techniques for Photoreceptor Loss in Geographic Atrophy
Maria Schulz, Sairi Zhang, Jeong W. Pak, Rick Voland, Mark Banghart, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: This study compares two methods for assessing ellipsoid zone (EZ) loss on optical coherence tomography (OCT): traditional …
Ellipsoid Zone Integrity Index: A Novel OCT Biomarker in AMD
Bethany M. Erb, Elaine Botros, Thomas F. Saunders, Anna-Maria Haas, Rick Voland, Rachel Linderman, Barbara A. Blodi, Amitha Domalpally, Karl G. Csaky Abstract Purpose: Change in geographic atrophy (GA) area as measured by fundus autofluorescence …
Multimodal Imaging Assessment of Risk Factors for GA Progression
Thomas Saunders, Jeong W. Pak, Rick Voland, Karl G. Csaky, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a multifactorial disease posing challenges in predicting progression. While prior studies have identified key …
OCT Risk Factors for Geographic Atrophy Progression
Jeong W. Pak, Thomas Saunders, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a complex disease with challenges in predicting its progression. While previous studies have highlighted key risk factors …
Deep Learning-Based Quantification of GA Area on OCT Scans
Rushi N. Mankad, Madeline Pflasterer-Jennerjohn, Rachel E. Linderman, Robert Slater, Amitha Domalpally Abstract Purpose: The consensus of Atrophy (CAM) criteria provides a robust framework for evaluating geographic atrophy (GA) with optical coherence tomography (OCT) scans. …
AI-based Measurement of GA Area for Screening In Clinical Trials
Mohammed Younis, Robert D. Slater, Caleb Pacheco, Sairi Zhang, Rick Voland, Rachel E. Linderman, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop and validate a transfer learning model for measuring geographic atrophy (GA) area using …
Predicting Geographic Atrophy Risk Using Autofluorescence Imaging and Artificial Intelligence
Robert D. Slater, Apoorva Safai, Madeline Pflasterer-Jennerjohn, Jennifer Heathcote, Rachel E. Linderman, Pallavi Tiwari, Emily Chew, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is the end stage of non-exudative AMD. Prevention strategies are essential to …
Comparison of GA measurements among ORC, OCT, and FAF imaging
Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) …
Correlating Fundus Flavoprotein Fluorescence with Structural Changes in Geographic Atrophy
Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration …
Prediction of Geographic Atrophy Enlargement using Various Deep Learning Approaches (2023)
Amitha Domalpally, Robert Slater, Mark Banghart, Roomasa Channa, Donald S. Fong, Barbara Blodi Abstract Purpose: Fundus autofluorescence (FAF) imaging is used to monitor geographic atrophy (GA) growth inclinical trials. There is significant variability in the …
Fundus AutoFluorescence Risk Factors for Progression of Geographic Atrophy in the Age-Related Eye Disease Study 2 (2018)
Jeong W. Pak, Amitha Domalpally, Elivira Agron, Ronald Danis, Traci E. Clemons, Emily Y. Chew, and the AREDS2 Research Group Abstract Purpose: To identify risk factors for progression of geographic atrophy (GA) from autofluoresence (AF) …
Index of Non Circularity as a Predictor for Progression in Eyes with Geographic Atrophy (GA) (2013)
Ronald P. Danis, Amitha Domalpally, Ellie Corkery, Ruth Shaw, Ashwini Narkar, Jim White Abstract Purpose: Given that baseline area and configuration of GA are associated with its progression rate, we hypothesized that a non circular …
Index of Non-Circularity of Areas of Geographic Atrophy (GA) is Related to Progression Rate (2012)
Ronald P. Danis, Amitha Domalpally, Larry D. Hubbard, Ashwini Narkar, James White, Emily Chew, Traci Clemons Abstract Purpose: We evaluated a parameter based upon an indirect measure of the extent to which the shape of …
Features Associated with Geographic Atrophy from Autofluorescence Images (2012)
Amitha Domalpally, Ronald P Danis, Ashwini Narkar, Barbara A. Blodi, Emily Chew, Traci Clemons Abstract Purpose: To evaluate the features associated with progression of Geographic Atrophy (GA) from Autofluorescence (AF) images. Methods: AF images (from …
Evaluation of Precursors of Geographic Atrophy associated with Age-Related MMacular Degeneration (AMD) in the Age-Related Eye Disease Study 2 (AREDS2) (2010)
Jane R. Armstrong, James White, Amitha Domalpally, Ronald P. Danis, Barbara Blodi, Qian Peng, Michael L. Klein, AREDS2 Research Group. Abstract Purpose: To assess retinal precursors of Geographic atrophy (GA) in digital images from the …