Zhe Liu, Amitha Domalpally, Amy E. Millen, Barbara A. Blodi, Thomas P. Lawler, Billy R. Hammond, Steven T. Bailey, Robert B. Wallace, Karen M. Gehrs, Ronald Gangnon, Lesley Tinker, Julie A. Mares Abstract Purpose: Macular …
Posters
Accuracy of Longitudinal AI based EZ Loss Quantification on OCT in Geographic Atrophy
Shelby Storm, Madeline Pflasterer-Jennerjohn, Robert Slater, Rachel Linderman, Jeong W. Pak, David Lopez, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Ellipsoid zone (EZ) loss is increasingly used as an endpoint in geographic atrophy (GA) trials, …
Real World Validation of Optos AI Algorithm for GA area Measurement
Reeva Faisal, Caleb Pacheco, Robert Slater, Mohammed S. Younis, Jomol Matthew, Marine Nalbandyan, Amitha Domalpally, Roomasa Channa Abstract Purpose: Optos ultrawide field imaging is widely used in routine care to monitor Geographic Atrophy (GA) progression …
Multimodal Evaluation of Macular Atrophy Associated with Neovascular AMD
Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, David Lopez, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Macular atrophy (MA) contributes to visual decline in treated macular neovascularization (MNV), yet identifying MA on OCT in the …
AI-based Multilayer OCT Segmentation Model For Macular Edema
Justin Bitner, Rachel Linderman, Aadhi Balasubramanian, Madeline Pflasterer-Jennerjohn, Jeong W. Pak, Robert Slater, Roomasa Channa, Lucas Maakested, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To train and assess an artificial intelligence (AI)-based OCT segmentation with …
Association of RPD with Early Stage of AMD
Jeong W. Pak, David Lopez, Emily Y. Chew, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Reticular pseudodrusen (RPD) is associated with increased risk of progression to late age-related macular degeneration (AMD), particularly geographic atrophy (GA). …
Real World Deployment of a Prescreening Algorithm for Geographic Atrophy
Thomas Saunders, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Area of geographic atrophy (GA) is a primary enrollment criterion in clinical trials. Current practices rely on clinicians to screen subjects for …
Comparison of Lesion Annotation Across 7-Field and Ultrawide Field Imaging in Diabetic Retinopathy (COLA)
Cole Bacig, Nancy Barrett, Kristi Dohm, Amitha Domalpally, Barbara Blodi Abstract Purpose: The gold standard for diabetic retinopathy (DR) evaluation is the Early Treatment Diabetic Retinopathy Study (ETDRS) 12-step severity scale (DRSS), based on stereoscopic …
Characterizing Intermediate AMD Biomarkers on OCT: Methods and Reproducibility
Jennifer Heathcote, Jordan Winkler, Jeong W. Pak, Rick Voland, Barbara Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and assess intergrader agreement for intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers in …
Comparison of Measurement Techniques for Photoreceptor Loss in Geographic Atrophy
Maria Schulz, Sairi Zhang, Jeong W. Pak, Rick Voland, Mark Banghart, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: This study compares two methods for assessing ellipsoid zone (EZ) loss on optical coherence tomography (OCT): traditional …
Ellipsoid Zone Integrity Index: A Novel OCT Biomarker in AMD
Bethany M. Erb, Elaine Botros, Thomas F. Saunders, Anna-Maria Haas, Rick Voland, Rachel Linderman, Barbara A. Blodi, Amitha Domalpally, Karl G. Csaky Abstract Purpose: Change in geographic atrophy (GA) area as measured by fundus autofluorescence …
Multimodal Imaging Assessment of Risk Factors for GA Progression
Thomas Saunders, Jeong W. Pak, Rick Voland, Karl G. Csaky, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a multifactorial disease posing challenges in predicting progression. While prior studies have identified key …
AI-enabled multi-disease OCT segmentation
Caleb Pacheco, Rachel E. Linderman, Madeline Pflasterer-Jennerjohn, Mark Banghart, Robert D. Slater, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop an artificial intelligence (AI) enabled OCT segmentation algorithm specifically tailored for diabetic macular edema (DME), …
OCT Risk Factors for Geographic Atrophy Progression
Jeong W. Pak, Thomas Saunders, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a complex disease with challenges in predicting its progression. While previous studies have highlighted key risk factors …
Deep Learning-Based Quantification of GA Area on OCT Scans
Rushi N. Mankad, Madeline Pflasterer-Jennerjohn, Rachel E. Linderman, Robert Slater, Amitha Domalpally Abstract Purpose: The consensus of Atrophy (CAM) criteria provides a robust framework for evaluating geographic atrophy (GA) with optical coherence tomography (OCT) scans. …
Artificial Intelligence (AI) enabled pre-screening for Diabetic Retinopathy (DR) clinical trials
Nancy Barrett, Robert Slater, Rachel E. Linderman, Rick Voland, Claire Calhoun, Jennifer K. Sun, Barbara A. Blodi, Amitha Domalpally, with the DRCR Retina Network Abstract Purpose: Preventive strategies to slow progression of diabetic retinopathy (DR) …
Characterization of OCT biomarkers and endpoints in intermediate AMD
Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and intergrader agreement for assessing intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers …
Diabetic Retinal Disease Characterization: Electronic Health Record Data Compared To Reading Center Grading Of Fundus Images
Kristi Dohm, Mozhdeh Bahrainian, Nancy Barrett, Rick Voland, John Garrett, Jomol Mathew, Michael D. Abramoff, Barbara Blodi, Amitha Domalpally, Roomasa Channa Abstract Purpose: Validity of diabetic retinal disease (DRD) severity level as documented in electronic …
AI-based Measurement of GA Area for Screening In Clinical Trials
Mohammed Younis, Robert D. Slater, Caleb Pacheco, Sairi Zhang, Rick Voland, Rachel E. Linderman, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop and validate a transfer learning model for measuring geographic atrophy (GA) area using …
Methodology and Reproducibility of Nonperfusion Area on UWF-FA
Mary Wilda, Rachel Halweg, Cynthia Hurtenbach, Kristi Dohm, Justin Parks, Ruth Shaw, Sheila Watson, Kari Moseman, Rick Voland, Barbara A. Blodi Abstract Purpose: To investigate the reproducibility of nonperfusion area measurements from ultrawide field fluorescein …
Predicting Geographic Atrophy Risk Using Autofluorescence Imaging and Artificial Intelligence
Robert D. Slater, Apoorva Safai, Madeline Pflasterer-Jennerjohn, Jennifer Heathcote, Rachel E. Linderman, Pallavi Tiwari, Emily Chew, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is the end stage of non-exudative AMD. Prevention strategies are essential to …
Comparison of GA measurements among ORC, OCT, and FAF imaging
Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) …
Correlating Fundus Flavoprotein Fluorescence with Structural Changes in Geographic Atrophy
Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration …
Prediction of Geographic Atrophy Enlargement using Various Deep Learning Approaches (2023)
Amitha Domalpally, Robert Slater, Mark Banghart, Roomasa Channa, Donald S. Fong, Barbara Blodi Abstract Purpose: Fundus autofluorescence (FAF) imaging is used to monitor geographic atrophy (GA) growth inclinical trials. There is significant variability in the …
Longitudinal Analysis of Age-Related Macular Degeneration in the AMD Ryan Initiative Study (ARIS) (2023)
Jeong W. Pak, Gelique Ayala, Cynthia Hurtenbach, Christine Orndahl, Tiarnan DL Keenan, Frederick L. Ferris, C. P Wilkinson, Traci Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year observational study of participants …
Comparison of Standard 7-Field, Clarus, and Optos Ultra-Widefield Imaging Systems for Diabetic Retinopathy Assessment (2023)
Nancy Barrett, Nicole Duncan, Christian Kim, Sheila Watson, Andy Ewen, Lauren Kroth, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Advances in ultrawide-field color (UWF-C) imaging technology have enabled visualization of the entire retina. This …
Visual Correlation of OCT-Angiographic Features in Neovascular Age-Related Macular Degeneration (2023)
Kevin Elwood, Rachel Linderman, Jeong Pak, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: OCT-Angiography (OCTA) presents numerous features with uncertain clinical significance in neovascular age-related macular degeneration (NVAMD). We performed a retrospective, observational, cross-sectional, …
Multimodal Assessment of Incomplete Retinal Pigment Epithelial Outer Retinal Atrophy (iRORA) and Nascent Geographic Atrophy (nGA) in Age-Related Macular Degeneration (2023)
Gelique Ayala, Jeong Pak, Kenny Taylor, Cynthia Hurtenbach, Barbara Blodi, and Amitha Domalpally Abstract Purpose: To compare SD-OCT defined iRORA and nGA lesions to Fundus Autofluorescence (FAF) and Color Fundus Photography (CFP) Methods: Subjects enrolled …
A Comparison of Neovascular Age-Related Macular Degeneration Features in OCT Angiography and Fluorescein Angiography (2013)
Jordan Winkler, Rachel Linderman, Jeong Pak, Mary Wilda, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Numerous pathological features in neovascular age-related macular degeneration (nAMD) can be assessed on both OCT-Angiography (OCTA) and fluorescein angiography …
Assessing Disorganization of Retinal Inner Layers in Long Term Follow Up of SCORE2 Trial (2023)
Jonathan Le, Barbara Blodi, Amitha Domalpally, Rick Voland, Paul VanVeldhuisen, Neal Oden, Michael Ip, Ingrid U. Scott Abstract Purpose: To determine the association of disorganization of the retinal inner layers (DRIL) with central subfield thickness …