Gelique Ayala, Jeong Pak, Kenny Taylor, Cynthia Hurtenbach, Barbara Blodi, and Amitha Domalpally Abstract Purpose: To compare SD-OCT defined iRORA and nGA lesions to Fundus Autofluorescence (FAF) and Color Fundus Photography (CFP) Methods: Subjects enrolled …
Research & Updates
A Comparison of Neovascular Age-Related Macular Degeneration Features in OCT Angiography and Fluorescein Angiography (2013)
Jordan Winkler, Rachel Linderman, Jeong Pak, Mary Wilda, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Numerous pathological features in neovascular age-related macular degeneration (nAMD) can be assessed on both OCT-Angiography (OCTA) and fluorescein angiography …
Assessing Disorganization of Retinal Inner Layers in Long Term Follow Up of SCORE2 Trial (2023)
Jonathan Le, Barbara Blodi, Amitha Domalpally, Rick Voland, Paul VanVeldhuisen, Neal Oden, Michael Ip, Ingrid U. Scott Abstract Purpose: To determine the association of disorganization of the retinal inner layers (DRIL) with central subfield thickness …
Imaging Features of Intraretinal Microvascular Abnormalities in Diabetic Retinopathy (2023)
Christian Kim, Jeong W. Pak, Nancy Barrett, Nicole Duncan, Mary K. Wilda, Kristi Dohm, Jen Heathcote, Barbara. A. Blodi, Rick Voland, Amitha Domalpally Abstract Purpose: To compare characteristics of intraretinal microvascular abnormalities (IRMA) on color …
Influence of Race on Training Data Quality for Artificial Intelligence (AI) Algorithms (2022)
Amitha Domalpally, Rick Voland, Robert Slater, Ellie Corkery, Pamela Vargo, Rebecca Kuhtz, James Reimers, Roomasa Channa, Barbara Blodi Abstract Purpose: Diabetic retinopathy (DR) severity level is evaluated from stereoscopic 7-field color photographs by masked graders …
Implementation of a Large-Scale Retinal Image Curation Workflow Using Deep Learning Framework (2022)
Rohit Balaji, Jen Heathcote, Robert Slater, Nancy Barrett, Rick Voland, Vesna Tomic, Jared McDonald, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: The development of artificial intelligence (AI) algorithms for analyzing retinal pathologies requires training based …
Artificial Intelligence (AI) enabled pre-screening for Diabetic Retinopathy (DR) clinical trials (2022)
Nancy Barrett, Robert Slater, Roomasa Channa, Barbara Blodi, Amitha Domalpally Abstract Purpose: Preventive therapies to reduce progression of non-proliferative DR (NPDR) to proliferative DR are underway. Clinical trial enrollment criteria typically include a baseline DR …
Multimodal Imaging Evaluation of Age-Related Macular Degeneration (AMD) in the AMD Ryan Initiative Study (ARIS) (2022)
Andrew Dieu, Cynthia Hurtenbach, Jeong W. Pak, Tiarnan D. Keenan, Frederick L. Ferris, Charles P. Wilkinson, Christine Orndahl, Traci E. Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year, multicenter, international, prospective, …
Prevalence and Characteristics of Reticular Pseudodrusen in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2) (2021)
Jeong W Pak, SC Cleland, Amitha Domalpally, Zhe Liu, Barbara Blodi, S Bailey, K Gehrs, R Wallace, L Tinker, and Julie A. Mares Abstract Purpose: Reticular pseudodrusen (RPD) have been identified as an independent risk …
Ellipsoid Zone Status in Eyes with Retinal Vein Occlusion in the Study of COmparative Treatments for REtinal Vein Occlusion 2 (SCORE2) (2019)
Chandana Papudesu, Amitha Domalpally, Neal Oden, Paul Van Veldhuisen, Ingrid U. Scott, Michael S. Ip, Barbara A. Blodi Abstract Purpose: To evaluate the status of the ellipsoid zone (EZ) assessed by spectral domain optical coherence …
Comparison of Diabetic Retinopathy Severity Level Assessment Between Standard 7-field Imaging and Ultrawide Field Color Imaging (2019)
Kristi Dohm, Nancy Barrett, Kyle McDaniel, Barbara Blodi, Amitha Domalpally Abstract Purpose: Diabetic retinopathy has traditionally been evaluated using the Early Treatment Diabetic Retinopathy Severity Scale (ETDRS) from 7-field (7F) stereoscopic color photographs and is …
Characteristics of Reticular Pseudodrusen in AREDS2 (2019)
Meghana Agni, Jeong W. Pak, Amitha Domalpally, Emily Y. Chew Abstract Purpose: To assess the correlation between peripheral non-perfusion from ultrawide field fluorescein angiography (UWF FA) and Early Treatment Diabetic Retinopathy Severity (ETDRS) level from …
Correlation of peripheral non-perfusion from ultrawide field fluorescein angiography to color ETDRS severity level in eyes with diabetic retinopathy (2019)
Ellie Corkery, Kyle McDaniel, Amitha Domalpally, Barbara Blodi Abstract Purpose: To assess the correlation between peripheral non-perfusion from ultrawide field fluorescein angiography (UWF FA) and Early Treatment Diabetic Retinopathy Severity (ETDRS) level from color fundus …
Comparable Growth Rates of Bilateral Geographic Atrophy due to Age-related Macular Degeneration (2019)
Jeong W. Pak, Amitha Domalpally, Kyle McDaniel, Barbara Blodi Abstract Purpose: To evaluate growth rate and characteristics of bilateral geographic atrophy (GA) associated with age-related macular degeneration (AMD) from fundus color and autofluorescence images Methods: …
Utility of Ultra-Widefield Imaging in Patients with Inherited Retinal Diseases (2019)
Rachael Lyerla, Nickie Stangel, Angie Adler, Kevin Vo, Melanie Schmitt, Kimberly Stepien Abstract Purpose: With emerging therapies underway for Inherited Retinal Diseases (IRDs), better documentation and qualitative assessment of peripheral retinal findings in these unique …
Fundus AutoFluorescence Risk Factors for Progression of Geographic Atrophy in the Age-Related Eye Disease Study 2 (2018)
Jeong W. Pak, Amitha Domalpally, Elivira Agron, Ronald Danis, Traci E. Clemons, Emily Y. Chew, and the AREDS2 Research Group Abstract Purpose: To identify risk factors for progression of geographic atrophy (GA) from autofluoresence (AF) …
Correlation of Optical Coherence Tomography Angiography Vascular Density to Color ETDRS Severity Level in Eyes with Diabetic Retinopathy (2018)
Ellie Corkery, Amitha Domalpally, Dawn Myers, Jeong W. Pak, Ralph Trane, Barbara Blodi Abstract Purpose: Diabetic retinopathy severity is evaluated using color fundus photographs (FP) employing the Early Treatment Diabetic Retinopathy Severity (ETDRS) scale. Optical …
Comparison of Foveal Avascular Zone Metrics in Diabetic Retinopathy (2018)
Kimberly Stepien, Ellie Corkery, Sheila Watson, Cynthia Hurtenbach, Ralph Trane, Jeong Won Pak, Amitha Domalpally Abstract Purpose: Foveal avascular zone (FAZ) abnormalities are known in diabetic retinopathy (DR) and may prove useful as a biomarker …
Evaluation of Diabetic Retinopathy from UltraWide Field Color Photographs (2018)
Nancy Barrett, Kristine Lang, Amitha Domalpally, Ellie Corkery, Ralph Trane, Barbara Blodi Abstract Purpose: Diabetic retinopathy (DR) has traditionally been evaluated using Early Treatment Diabetic Retinopathy Study (ETDRS) levels from stereoscopic 7 field color photographs. …
Agreement in CNV Lesion Location as Assessed by SD-OCT vs. Fluorescein Angiography (2018)
Mary K. Wilda, Ellie Corkery, Cynthia Hurtenbach, Amitha Domalpally, Ralph Trane, Barbara A. Blodi Abstract Purpose: Considered the gold standard in assessing location of choroidal neovascular (CNV) lesions, fluorescin angiography (FA) is the primary imaging …
Evaluation of Diabetic Retinopathy Using the ETDRS Severity Scale – Is There a Gold Standard? (2018)
Amitha Domalpally, Ralph Trane, James Reimers, Barbara Blodi Abstract Purpose: The Early Treatment Diabetic Retinopathy Study (ETDRS) study established a 12 step scale to document the severity of diabetic retinopathy (DR) using 7 field stereoscopic …
Reading Center Measurement of Capillary Non-Perfusion Using Ultrawidefield (UWF) Fluorecein Angiography in Two Prospective Clinical Trials of Retinal Vein Occlusion and Diabetic Retinopathy (2017)
Ellie Corkery, Amitha Domalpally, Ruth Shaw, Kelly Warren, Sheila Watson, Barbara Blodi Abstract Purpose: According to the October 2016 Report from the NEI/FDA Diabetic Retinopathy Clinical Trial Design and Endpoints workshop (Investigative Ophthalmology & Visual …
Standardization of OCT Derived Central Retinal Thickness with Custom Segmentation Software (2017)
Gregory Sovinski, Amitha Domalpally, Dawn Myers, Yijun Huang, Barbara Blodi Abstract Purpose: Central Retinal Thickness (CRT) is a measure derived from Optical Coherence Tomography (OCT) scans and is an important outcome in clinical trials. Differences …
Drusen Area Measured from Color Photographs Compared to RPE and Drusen Volume from SD-OCT in Eyes with AMD over One Year (2017)
Ronald P Danis, Amitha Domalpally, Ralph Trane, Jeong W Pak Abstract Purpose: To quantitatively evaluate the relationship between drusen area from photographs and drusen [a1.1]volume from SDOCT volume scans with respect to baseline association, AREDS …
Optical Coherence Tomography in the Evaluation of Neovascular Lesions and Serous Pigment Epithelial Detachments in Polypoidal Choroidal Vasculopathy (2016)
Eric Weinlander, Amitha Domalpally, Ellie Corkery, Barbara Blodi Abstract Purpose: Spectral domain optical coherence tomography (SD-OCT) has not routinely been used to measure features of polypoidal choroidal vasculopathy (PCV) due to its anatomic complexity. We …
Standardized Assessment of Drusen Measurements from SDOCT Scans in Dry Age Related Macular Degeneration (2015)
Amitha Domalpally, Yijun Huang, Dawn Myers, Taylor Starnes, Zhe Liu, Ronald P. Danis, Barbara A. Blodi Abstract Purpose: To compare retinal pigment epithelium (RPE) and retinal thickness assessments made with SDOCTin eyes with dry AMD …
Ultra Wide Field Autofluorescence Imaging in Age Related Macular Degeneration Optos Peripheral Retina (OPERA) Age Related Eye Disease Study 2 (AREDS2) Ancillary Study (2014)
Amitha Domalpally, Ronald Danis, Emily Chew, Srinivas Sadda, Traci Clemons, Thomas R Friberg, and the AREDS2 Research Group Abstract Purpose: To characterize abnormalities in the peripheral retina using ultrawidefield (UWF) autofluorescence (AF) images in eyes …
Evaluation of Lens Opacities Using Fundus Reflex Photographs in the Age-Related Eye Disease Study 2 (AREDS2) (2013)
Erika Treichel, Amitha Domalpally, Ronald Danis, Susan Reed, Ashwini Narkar, Traci Clemons, Emily Chew, and the AREDS2 Research Group Abstracts Purpose: To describe the methodology for evaluation of cortical and posterior subcapsular cataracts using digital …
A computer-aided manual segmentation method for Spectral Domain OCT images yields increased inter-grader reproducibility (2013)
Yijun Huang, Ronald P Danis, Jeong W. Pak, Shiyu Luo, James White, Xian Zhang, Ashwini Narkar, Amitha Domalpally Abstract Purpose: To develop a computer-aided manual segmentation method (EdgeSelect) for SD-OCT images, and compare its segmented …
Index of Non Circularity as a Predictor for Progression in Eyes with Geographic Atrophy (GA) (2013)
Ronald P. Danis, Amitha Domalpally, Ellie Corkery, Ruth Shaw, Ashwini Narkar, Jim White Abstract Purpose: Given that baseline area and configuration of GA are associated with its progression rate, we hypothesized that a non circular …